While p53 gene mutations are rare in ccRCC, these tumors often resist DNA-damage- based therapies, suggesting alternative mechanisms suppressing wild-type p53 in ccRCC. Therefore, reactivating this ...

The importance of understanding DNA repair Our cells protect their DNA by constantly monitoring and repairing any damage. When DNA is damaged, internal signals activate within the cell to pinpoint ...

Boehringer Ingelheim has signed a €500m ($572m) agreement with UK-based biotech Tessellate Bio to co-develop targeted cancer ...

Even basic cell division can introduce damage. Repetitive segments can become tangled, and random hits can cause cracks in the DNA structure. Each time a cell copies the DNA blueprint, dozens of ...

Double-strand breaks (DSBs) represent severe DNA damage formation because they split both DNA helix strands at the same time. DSBs stand as severe DNA damage categories because these injuries ...

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License . Mol Cancer Ther (2025) 24 (4): 497–510. Murine double minute 2 (MDM2) is an E3 ligase ...

A hallmark of cancer development and progression characterized by the accumulation of DNA damage; genome instability manifests as increased genetic variation across the genome, including ...