For instance, the USP7 inhibitor P5091 has shown promise in the treatment of multiple myeloma by promoting the ubiquitination and degradation of MDM2, thereby activating the p53 pathway (10). The ...

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Immunohistochemistry studies showed the malignant cells were diffusely positive for murine double minute 2 (MDM2) with weak positivity for smooth muscle antibody (SMA). They are negative for ...