MOSCOW, March 18 (Reuters) - Western companies that "slammed the door defiantly" when they left Russia will not be allowed to buy back the businesses they quit for small amounts of money or fill ...

Western is one of the most iconic and distinctive genres in cinema and television. From sprawling ranches to dusty towns, rugged cowboys in hats to intense gunfights at high noon, westerns have a way ...

Mechanistically the combination of these two agents decreased the expression of MDM2, without affecting p53 activation or its expression. Therefore, this short study provides the foundation to ...

MDM2的表达本身是由p53诱导的，可能是p53在正常细胞周期中自我调节其活性的一种方式。然而，MDM2的过表达会导致p53调控的生长控制丧失，从而导致细胞增殖失控。此外，MDM2还可以结合视网膜母细胞瘤肿瘤抑制蛋白（Rb），并抑制其生长调控功能。MDM2通过结合 ...

TFE3 and TFEB contribute to sustain p53-dependent response by stabilizing p53 protein levels. In TFEB/TFE3 DKOs, p53 half-life is significantly decreased due to elevated Mdm2 levels. Transcriptional ...

Mechanistically, BAG2 binds to mutp53 and translocates to the nucleus to inhibit the MDM2-mutp53 interaction, and MDM2-mediated ubiquitination and degradation of mutp53. Thus, BAG2 promotes mutp53 ...