It was subsequently found to drive degradation of subunits in a transcriptional repressor complex ‘LHC’, comprised of the histone demethylase LSD1, the histone deacetylase HDAC1 (or HDAC2 ...

实验也证明，VOR 确实减弱了巨噬细胞对肿瘤细胞的吞噬能力，而用 CD47 阻断抗体可以逆转这一现象。而且，不同 HDAC 亚型抑制剂实验表明，抑制 I 型 HDAC（HDAC1/2/3）和 IIb 型 HDAC（HDAC6）会显著上调 CD47 表达。 然后是 “内源性 HDACi 在 CRC 肿瘤微环境中连接微生物 ...

Gastric cancer remains the fourth most frequently diagnosed malignancy and the fifth leading cause of cancer-related mortality worldwide owning to the lack of efficient drugs and targets for therapy.

In patients with castration-resistant prostate cancer (CRPC), clinical resistances such as androgen receptor (AR) mutation, AR overexpression, and AR splice variants (ARVs) limit the effectiveness of ...

Recent studies have challenged the prevailing dogma that transcription is repressed during mitosis. Transcription was also proposed to sustain a robust spindle assembly checkpoint (SAC) response. Here ...