撰文 | 冉茂双 责编 | 周叶斌MYCN的异常表达与多种人类癌症的肿瘤发生密切相关，其中MYCN扩增是高危神经母细胞瘤 (NB) 的主要遗传驱动因素，也是临床上最强的独立不良预后因素。MYCN基因编码致癌转录因子N-Myc在正常神经前体细胞中泛素化 ...

为探究胰腺癌（PDAC）表型异质性的遗传机制，研究人员开展 MYC ecDNA 研究，发现其促进肿瘤异质性和可塑性，意义重大。 胰腺癌（Pancreatic Ductal Adenocarcinoma，PDAC）作为一种恶性程度极高的消化系统肿瘤，其预后极差，5 年生存率仅约 10%。在胰腺癌的发生发展过程中，MYC 基因的异常扩增与肿瘤的侵袭性和不良预后密切相关。MYC ...

Researchers sought to evaluate differences in ctDNA profiles, use of targeted treatments, and overall survival between Black and White patients with metastatic breast cancer.

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...

We tested the guardian molecule in mice that had highly potent cancer mutations in the p53 and Myc genes. PROX1 was able to override the influence of such strong cancer drivers and suppress the ...

We tested the guardian molecule in mice that had highly potent cancer mutations in the p53 and Myc genes. PROX1 was able to override the influence of such strong cancer drivers and suppress the ...

为排除 p53 和 HIPK2 的影响，在 p53 缺失的 H1299 细胞和 HIPK2 缺失的 HeLa ... 通过共免疫沉淀实验，发现内源性 MDM2 能与痉挛蛋白 - DDK - MYC 共沉淀，而与阴性对照 DDK - MYC 不结合，且两者在细胞质和细胞核中存在共定位，表明 MDM2 与痉挛蛋白在细胞内形成复合物。

The key tumor suppressor protein p53, additionally known as p53, represents an attractive target for the development and management of anti-cancer therapies. p53 has been implicated as a tumor ...