Using single-cell transcriptomics, they tracked dynamic changes in various cell types, including monocytes, macrophages ... and disruption of the ECM. To address these issues, the researchers ...

Department of Physiology, State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical ...

The researchers also discovered that when these cells, called macrophages, eat live bacteria it triggers an inflammation response. But when they eat dead bacteria it doesn't. "When phagocytic ...

Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...

This important study reveals that disrupting fatty acid metabolism in macrophages significantly restricts the growth of Mycobacterium tuberculosis, showing that impaired lipid processing triggers ...

Here we studied mice implanted with GFP-expressing melanoma cells to decipher early LN colonization events. We show that Siglec1-expressing subcapsular sinus (SCS) macrophages provide anchorage to ...

A greater appreciation of the role of the inflammatory response and the interaction between macrophages and the extracellular matrix (ECM) is required in order to provide greater insight into tissue ...

It is characterized by excessive deposition of extracellular matrix (ECM) proteins by myofibroblasts and impaired degradation by macrophages. This ultimately destroys the normal structure of an organ, ...