Macrophages are vital sentinels in innate immunity, and their functions cannot be performed without internal metabolic reprogramming. Mitochondrial dynamics, especially mitochondrial fusion and ...

Dec. 10, 2024 — In a single IV injection, a gene therapy targeting cBIN1 can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the ...

Department of Pediatrics, Columbia University, New York, NY, United States Collectively, these findings suggests that Mtb survival hinges on its ability to manipulate host macrophage metabolism. By ...

kuleuven.be Intestinal resident macrophages are at the front line of host defence at the mucosal barrier within the gastrointestinal tract and have long been known to play a crucial role in the ...

Macrophages, part of the innate immune system, can exhibit a form of immune memory by adjusting their molecular signaling after an infection. This adaptation can either enhance or reduce their ...

Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma 74078, United States Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State ...

Department of Immunology, Department of Rheumatology, and School of Basic Medical Sciences, Zhongshan Hospital, Fudan University, Shanghai, China. (X.Y., X.Z., Y.T ...

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States Alnylam ...

One in 3,000 People at Risk of Punctured Lung from Faulty Gene -- Almost 100 Times Higher Than Previous Estimate Apr. 7, 2025 — As many as one in 3,000 people could be carrying a faulty gene ...

Now, the self-styled gene editing pioneer is trying to stage a comeback with another controversial project, aiming to use gene editing to prevent Alzheimer’s disease in future generations.