为探究抑郁症发病机制及干预靶点，研究人员以慢性社会挫败应激（CSDS）小鼠为模型，研究抑郁样行为、肠道微生物组和粪便代谢组变化。结果发现三者在不同应激阶段有显著改变，还确定了关键细菌和代谢物，为抑郁症研究提供新视角。

为探究短链脂肪酸（SCFA）生物疗法对 1 型糖尿病（T1D）的影响，研究人员开展相关研究，发现其可延缓 T1D 进展，意义重大。 在健康领域，1 型糖尿病（T1D）一直是困扰医学界的难题。它是一种由 T 细胞驱动的自身免疫性疾病，发病机制颇为复杂。胰腺胰岛中产生胰岛素的 β ...

However, until this year, the 'human parts list' was still incomplete. We often forget that every gene, every protein and every cell is composed of even smaller parts – namely metabolites.

HOBOKEN, NY — Wiley, one of the world’s largest publishers and a global leader in research and learning, today announced the 2025 release of its Wiley Identifier of Natural Products (AntiBase Library ...

KEGG pathways enriched by differential metabolites primarily include arachidonic ... was prepared with dimethyl sulfoxide at a concentration of 1 × 10 4 μg/mL and stored at 4°C. Transcriptome and ...

2022). Fruit color are determined by pigment, of which flavonoids and carotene are the two most important pigments (Yu et al., 2022). Currently, transcriptome and metabolome analysis have been widely ...

However, anthocyanin components and the molecular mechanisms of anthocyanin biosynthesis in colored-leaf poplar remain unclear. Consequently, an integrative analysis of transcriptome and metabolome is ...

This work measures time-resolved metabolomes of 164 yeast mutants using a high-throughput method (FIA-MS). The dynamic, nontargeted measurements allow for an improved inference of gene function in the ...

Using leave-one-out cross validation, we also found that metabolome profiles could successfully ... Fourth, the pathway analysis is based on the KEGG data set. Although KEGG data set maximizes ...