A research group led by Nagoya University Graduate School of Medicine in Japan has uncovered a potential mechanism linking ...

Researchers from Charité - Universitätsmedizin Berlin and the Max Delbrück Center have identified the precise mechanism by ...

Microglia, the brain's immune cells, usually serve as diligent guardians. They eliminate intruders such as microbes and clear away cellular debris—including the plaques typical of Alzheimer's disease.

A new study reveals that inflammation during pregnancy may impair neurodevelopment in infants by reducing CD11c-positive ...

at immune cells known as microglia. Vital in both developing and mature brains, these cells help shape neurons, control how they communicate, keep an eye out for pathogenic intruders, and mediate ...

A research group led by Nagoya University Graduate School of Medicine in Japan has uncovered a potential mechanism linking maternal inflammation to ...

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to such cells in non-immunized controls, regardless of whether the treatment was ...

Lastly, certain genes, like TREM2 and APOE, are more active in microglia in response to treatment, helping these cells remove amyloid beta plaques, according to the findings. "A long-standing ...

A comprehensive Thought Leaders Invited Review in Brain Medicine highlights the crucial role of CD2-associated protein (CD2AP) in Alzheimer’s disease (AD). CD2AP influences amyloid-beta processing, ...

Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...