When mitochondria fail, the consequences can be devastating – particularly for children with genetic disorders that rob cells of their ability to produce energy. Now, researchers at the University of ...

In Parkinson’s disease (PD), damaged mitochondria build up in the dopaminergic system of the substantia nigra, partly due to impaired mitochondrial autophagy (mitophagy) and autophagosome accumulation ...

Researchers have identified a molecule that helps more mitochondria function properly. A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic ...

Researchers at the University of Gothenburg have identified a molecule that helps more mitochondria function properly. Mitochondrial diseases caused by POLG mutations vary in severity. In young ...

Researchers at the University of Gothenburg have identified a molecule that helps more mitochondria function properly. Mitochondrial diseases caused by POLG mutations vary in severity. In young ...

If successfully translated to humans, this approach could provide a means to personalize heteroplasmy-shifting treatment in patients, offering the possibility of restoring normal mitochondrial ...

"TMEM65 was of particular interest because it is a mitochondrial protein of unknown function," Dr. Elrod explained. "We also knew about a case report in which a young girl with a loss-of-function ...

In this way, the researchers ultimately discovered TMEM65 as a primary suspect in NCLX regulation. “TMEM65 was of particular interest because it is a mitochondrial protein of unknown function,” Dr.

Cells are the building blocks of life, acting like tiny power stations that keep the body functioning. However, sometimes the DNA within parts of the cell known as mitochondria becomes damaged, which ...

Enhancing the activity of the retromer complex, particularly the protein VPS35, improves mitochondrial function, offering potential therapeutic strategies for mitochondrial and age-related diseases.