catalyzed by a protein- tyrosine/threonine kinase termed MAP kinase kinase, or MEK (MAP kinase/ERK kinase). MAP kinase kinase (MKK) is remarkably specific for MAP kinase as the protein substrate and ...

However, IL3-induced BAD phosphorylation is as sensitive to inhibition of MAP kinase kinase as it is to inhibition of PI(3)K (and hence of PKB/Akt), whereas GM-CSF-induced BAD phosphorylation is ...