Work at Laekna Therapeutics Shanghai Co. Ltd. has led to the identification of new bicyclic heteroaromatic compounds acting as Myt1 kinase (PKMYT1) inhibitors potentially useful for the treatment of ...

To address these challenges, we explored the complementary targeting of PKMYT1, another G2/M checkpoint kinase with distinct yet overlapping functions to WEE1. Using 3D cultures of breast cancer cell ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

7R. Ken Coit College of Pharmacy, University of Arizona, Tucson, Arizona.

1 Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA 2 Pediatric Rheumatology ...

Furthermore, it is set to present new preclinical data on SGR-3515, an investigational Wee1/Myt1 inhibitor, and SGR-4174, a SOS1 inhibitor, at the American Association for Cancer Research (AACR) ...