Genome editing has advanced at a rapid pace with promising results for treating genetic conditions—but there is always room ...

integrating those elements into the bacterium’s genome (at the CRISPR locus), and using the RNAs produced from the integrated elements to direct destruction of the corresponding virus. In essence, the ...

called “spacers” into the CRISPR locus in the genome of the bacterial host. These spacers are later transcribed into crRNA that are loaded on Cas nucleases to target them to cleave and block recurring ...

Study: Activation of the imprinted Prader-Willi syndrome locus by CRISPR-based epigenome editing ... levels were not always ...

In 1993, Spanish researcher Francisco Mojica described what became known as a “CRISPR locus.” According to the Massachusetts Institute of Technology and Harvard University’s The Broad Institute, the ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...

“Since we wanted to activate specific genes – rather than change their sequence – we inactivated the DNA-cutting function of the Cas9 protein in CRISPR and used it only to find and bind to the PWS ...

Gene editing firm CRISPR Therapeutics has announced a collaboration with US biotech Nkarta to develop natural killer (NK) cell therapies for cancer. This latest agreement follows a major deal with ...