Moreover, homogeneous staining of high-density epitopes, such as neuronal nuclear antigen (NeuN), creates an additional challenge. Here, we evaluated different tissue transformation approaches to find ...

And when stains happen, it's easy to panic and start to throw every possible solution at the wall (literally) and hope it eradicates the mess. However, using the wrong stain solution often only makes ...

For the first time, researchers have identified that inflammation—long associated with multiple sclerosis (MS)—appears to cause increased mutations linked to MS progression. MS is a ...

We further found that neurons with accumulation of phospho-tau immunostaining contained rG4s, that rG4 structure can drive tau aggregation, and that rG4 staining density depended on APOE genotype in ...

Department of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, United States Biomedical Sciences Graduate Program, School of Medicine, University of ...

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Scale bars represent 20 μm. Figure 6. Representative examples of triple immunofluorescence staining of mouse brain tissue using 1% formaldehyde and 0.5% MeOH fixation. (A–D) For the entire figure, the ...