ChIP-qPCR results confirmed that Nrf2 directly binds to the GGTLC2 promoter region to regulate its expression, and crocin attenuated this binding interaction. Discussion: In conclusion, our findings ...

State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, ...

推荐阅读：本文聚焦 HNSCC 中 ferroptosis，阐述其分子机制与治疗策略，极具科研价值。 头颈部鳞状细胞癌（HNSCC）中 ferroptosis 的分子机制及治疗研究进展 一、ferroptosis 概述 ferroptosis 是一种受调控的、依赖铁的细胞死亡方式，脂质过氧化和线粒体功能障碍在其中 ...

Department of Health Management of the Guangdong Second Provincial General Hospital & Postdoctoral Research Station of Basic Medicine of the School of Medicine; Department of Bioscience and ...

FIGURE 3. The pathway of p53 and Nrf2 in ferroptosis. The generation of ROS, lipid peroxidation and iron homeostasis are the indispensable course in triggering ferroptosis. Nrf2 and p53 participate in ...

These experiments used the 4-octyl modification to ensure that itaconate could get into the cells. Itaconate’s anti-inflammatory action is thought to work by activating a signaling process in cells ...