血管内皮铁死亡与动脉粥样硬化密切相关，达格列净（DAPA）虽能延缓动脉粥样硬化进展，但机制不明。研究人员构建细胞和动物模型研究发现，DAPA 激活 RAP1B/NRF2/GPX4 信号通路、促进线粒体生物发生，减轻铁死亡，为防治动脉粥样硬化提供新依据。

A deeper understanding of osteosarcoma , the most common primary malignant bone tumor affecting children and adolescents, is ...

A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is ...

胃癌（GC）是全球最常见的恶性肿瘤之一，在癌症相关死亡率中排名第三，严重威胁着人类健康。在中国，胃癌的早期诊断率显著偏低，这主要是由于缺乏全面的早期筛查项目，且五年生存率不足 30%，表明患者的预后极差。由于对化疗产生原发性或获得性耐药，多达 40% ...

Background and aims Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. However, research on COX-2 ...

Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms ...

Chemoresistance is the most significant challenge affecting the clinical efficacy of the treatment of patients with gastric cancer (GC). Here we reported that transmembrane protein 160 (TMEM160) ...

SP600125 是一种有效的铁死亡 (ferroptosis) 抑制剂。SP600125 抑制自噬 (autophagy)，诱导凋亡 (apoptosis)。 体外实验：SP600125 是 ATP 竞争性的 c-Jun 氨基末端激酶 (JNK) 选择性抑制剂，IC50 为 40 nM 到 90 nM。SP600125 作用于 Jurkat T 细胞，抑制 c-Jun 磷酸化，IC50 为 5 ...

This antioxidant collapse occurred in parallel with the Transforming growth factor-beta (TGF-β)-mediated upregulation of pro-ferroptotic pathways and suppressed Nrf2 signaling, effectively disabling ...

在 2 型糖尿病模型 db/db 小鼠中玻璃体内注射过表达 FLOT1 的腺相关病毒（adeno-associated virus，AAV），并评估视网膜中 Nrf2、溶质载体家族 7 成员 11（solute carrier family 7 member 11，SLC7A11）和谷胱甘肽过氧化物酶 4（glutathione peroxidase 4，GPX4）的表达水平。研究表明 ...