COX-2 plays a pivotal role in ferroptosis during the progression of chronic liver disease, as it downregulates the Nrf2 signaling pathway, exacerbating ferroptosis, which is characterized by ...

A deeper understanding of osteosarcoma , the most common primary malignant bone tumor affecting children and adolescents, is ...

Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms ...

Reata Pharma has reported positive clinical results with one of its Nrf2 activators for mitochondrial diseases, just days after buying back rights from AbbVie. The positive data from a phase ...

Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression. Ferroptosis, driven by excessive lipid peroxides and iron-dependent ...

Chemoresistance is the most significant challenge affecting the clinical efficacy of the treatment of patients with gastric cancer (GC). Here we reported that transmembrane protein 160 (TMEM160) ...

A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is ...