胃癌（GC）是全球最常见的恶性肿瘤之一，在癌症相关死亡率中排名第三，严重威胁着人类健康。在中国，胃癌的早期诊断率显著偏低，这主要是由于缺乏全面的早期筛查项目，且五年生存率不足 30%，表明患者的预后极差。由于对化疗产生原发性或获得性耐药，多达 40% ...

A deeper understanding of osteosarcoma , the most common primary malignant bone tumor affecting children and adolescents, is ...

编辑推荐：针对胃癌化疗耐药难题，南昌大学第一附属医院团队揭示TMEM160通过招募E3连接酶TRIM37促进KEAP1的K48泛素化降解 ...

本文聚焦 Nrf2 在卵巢及相关疾病中的作用，揭示其抗氧化机制，为卵巢疾病治疗提供新思路。 引言 女性不孕症是一个全球性的健康问题，影响着数百万女性。其病因复杂，涵盖激素失衡、生殖系统疾病、年龄增长导致的卵子质量下降以及生活方式等因素。

A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is ...

Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms ...

COX-2 plays a pivotal role in ferroptosis during the progression of chronic liver disease, as it downregulates the Nrf2 signaling pathway, exacerbating ferroptosis, which is characterized by ...

Chemoresistance is the most significant challenge affecting the clinical efficacy of the treatment of patients with gastric cancer (GC). Here we reported that transmembrane protein 160 (TMEM160) ...