The paper by Gao et al. describes the effect of capsaicin on the NRF2/KEAP1 pathway. The authors carried out a set of in vitro and in vivo experiments that addressed the mechanisms of the protective ...

This important study suggests that capsaicin nanoparticle administration in rats activates the transcription factor Nrf2 by directly binding to its repressor KEAP1, leading to cytoprotective gene ...

DMPE-PEG-Fluorescein 是一种结合了二肉豆蔻酰基磷脂（DMPE）、聚乙二醇（PEG）和荧光素（Fluorescein）的多功能磷脂衍生物。其结构特点如下： DMPE：提供疏水性，能够与细胞膜或脂质体相互作用，增强分子的膜亲和性。 PEG：赋予分子良好的水溶性和生物相容性，减少 ...

Cell. 2012. Vol. 149:1060–1072 Zhang M, Zhang T, Song C, Qu J, Gu Y, Liu S, et al.. Guizhi Fuling Capsule Ameliorates Endometrial Hyperplasia through Promoting p62-Keap1-NRF2-mediated Ferroptosis.

1192, lxiv columns : ill., facsims., maps, ports. ; 35 cm.

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...

This process is further regulated by SQSTM1/p62. P62, a kind of ubiquitin-binding protein, competes with NRF2 in the Kelch motif of KEAP1 and increases the content of downstream Nrf2 by inactivation ...

Figure 1. Schematic representation showing Nrf2 translocation to the nucleus after dissociation from its inhibitory protein Keap1. In the nucleus, Nrf2 binds and activates ARE in the DNA, regulating ...