The study proposes that selective loss of DNA methylation at a subset of promoters is required for nucleosome retention and the establishment of epigenetic states that may influence embryonic gene ...

The epigenetic memory of a cell defines the set of modifications to the cell's deoxyribonucleic acid (DNA) that do not alter the DNA sequence, and have been inherited from the cell from which it ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Locusts, as devastating pests, can reversibly ...

Indeed, upon transcriptional inhibition, ADPr condensates were no longer observed (Fig. 1B). Because PARP14 was pulled down by ADP-ribose binding Af1521 macrodomain following IFNγ treatment in ...

Life begins with a tiny orchestra of stem cells, setting the stage for the body’s grand symphony of development. As the performance unfolds, a dynamic interplay of factors takes center stage, ...

Computational models of cells cannot be considered complete unless they include the most fundamental process of life, the replication and inheritance of genetic material. By creating a computational ...

This review describes targeting neutrophils as a potential therapeutic strategy for acute respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID-19), a pandemic caused by ...

Amino acid substitutions identified by the screen map to the nucleosome DNA entry-exit site. The strongest H3 mutants revealed widespread genomic changes, including increased sense-strand ...

To date, potent, selective and cell-active NSD2 inhibitors have not been described. A platform was established for the discovery of selective NSD2 inhibitors from quantitative high-throughput ...