The chain of nucleosomes is then compacted further and forms a highly organized complex of DNA and protein called a chromosome.

The observation by electron microscopists that chromatin appeared similar to beads on a string provided an early clue that nucleosomes exist (Olins and Olins, 1974; Woodcock et al., 1976).

This organization can be explained by weak interactions between nucleosomes, which are the repetitive blocks that fold the ...