suggesting orexin’s role in prioritizing exercise. However, blocking orexin signaling did not change the behavior of mice when they were offered only the running wheel and not the milkshake: Both ...

Of those choices, one was an exercise wheel and another was either ... Professor Burdakov says: 'This means that the primary role of the orexin system is not to control how much the mice move ...

Identifying whether components of total energy expenditure (EE) are affected by orexin receptor (OXR1 and OXR2) stimulation or antagonism with dual orexin receptor antagonists (DORAs) has ...

Selected research acheivements: Tesmer AL, Li X, Bracey E, Schmandt C, Polania R, Peleg-Raibstein D, Burdakov D (2024) Orexin neurons mediate temptation-resistant voluntary exercise. Nature ...