Orexin-A (American Peptides, Sunnyvale, CA, USA) was dissolved in artificial cerebrospinal fluid (Sigma-Aldrich, St Louis, MO, USA), which served as the vehicle control for orexin-A. The DORA (TCS ...

In 1998, we purified a novel neuropeptide orexin and showed that this peptide plays pivotal roles in the regulation of appetite and sleep. In this ERATO project, we showed that the administration of ...