宫颈癌是女性常见癌症，死亡率高。研究人员针对 HBD2 在宫颈癌中表达下调机制不明的问题，开展了 HPV16 E7 对 HBD2 表达影响的研究。结果发现 HPV16 E7 通过抑制 ASK1-p38 MAPK 通路下调 HBD2 表达，为宫颈癌治疗提供新思路。

Perry Dahl (who flew the P-38 Lightning), Capt. “Duke” Hedman (America’s first WWII ace, who flew P-40 Warhawks with the famed Flying Tigers), Capt. John Angel Chu (one of Duke’s fellow ...

Over the weekend, as Elon Musk launched into a barrage of social media posts criticizing one of the lead White House advisers for President Donald Trump’s aggressive tariff plan, Musk was going ...

为探究砷（As）对鲤鱼脾脏的毒性机制以及锌（Zn）是否能通过 P38 MAPK/Nrf2/HO-1 通路缓解 As 诱导的氧化应激和炎症损伤，研究人员开展相关研究。结果发现 Zn 可减轻 As 诱导的脾脏损伤，这为 Zn 的解毒机制及在水产养殖中减轻重金属毒性提供了新见解。 砷（As ...

Gift 5 articles to anyone you choose each month when you subscribe. In today’s news, Donald Trump’s tariffs announcement sends Australia’s sharemarket plunging, Norfolk Island is ...

Department of Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research ...

We found that lipopolysaccharide treatment triggered neutrophil activation in an HPK1-dependent manner. HPK1 enhanced intrinsic NF-κB/STAT3/p38-MAPK pathways and gasdermin D cleavage, leading to ...

Il-38Ns are easily distinguished by the presence of an odd-looking apparatus mounted above the cockpit which is part of the Novella P-38 surveillance suite. Though now on their way to the U.S ...