为解决依维莫司治疗乳腺癌疗效受限问题，研究人员开展褪黑素联合依维莫司治疗激素受体阳性乳腺癌的研究。结果显示联合用药可抑制 mTOR 通路、促进凋亡等，表明褪黑素或可作乳腺癌治疗佐剂，提升依维莫司疗效。

重度抑郁症是全球最严重的心理障碍之一，其终生患病率为10.6%。压力是抑郁的重要风险因素，在日常生活中普遍存在，短期的适度压力对生存有益，而长期的压力暴露会扰乱情绪稳态并导致抑郁。大脑如何动态应对压力仍然是一个谜团，因此理解特定神经回路中压力下细胞的 ...

Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao 266003, P. R. China Qingdao Key Laboratory of Thyroid, Diseases, Medical Research Center, Qingdao 266555, ...

The voting figures of Celebrity Big Brother have been revealed, with the numbers disclosing that Jack P Shepherd narrowly clinched the winning title. The Corrie star was closely followed by runner ...

Coronation Street actor Jack P Shepherd has been crowned as the winner of Celebrity Big Brother 2025 after a dramatic final on Friday (25 April). The star was named as the winner of the ITV ...

The S&P 500 gained more than 4% for the week as investors focused on Trump's generally optimistic tone on trade talks and Fed officials hinted at possible rate cuts as early as this summer.

With the Celebrity Big Brother final moments away, it's between JoJo Siwa, Chris Hughes, Danny Beard, Donna Preston, Jack P. Shepherd and Chesney Hawkes to take the crown. This series friendships have ...

Stocks ended Thursday in the green, driven by strong gains in megacap tech names as investors sought signs of progress in global trade. The S&P 500 closed at 5,484.77, up 2% and 108.91 points. The ...

5A. (6) In Figure S2A and Figure S2B, 17-month-old TRGL/Q175 mice show a decrease in pp70S6K and the p-ULK1/ULK1 ratio, but no changes are observed in autophagy-related markers. Do these results ...

Statistical significances between the two groups were analyzed by unpaired, two-tailed t-test. * P < 0.05. Oral mTORi INK engages mTOR target and induces downstream responses in the ALP in 7-mo-old ...