In this work, the authors determine the conformational ensemble of human P-glycoprotein during active ... use mRNA display to discover peptide inhibitors of BamA, an essential factor that ...

Debiopharm announces oral and poster presentations on data from their potential first-in-class compound Debio 1562M, a ...

Single-point mutations within the kinase domain of BCR–ABL constitute the most frequent cause of acquired resistance to ABL kinase inhibitors in patients with chronic myeloid leukaemia (CML ...

Calcitonin gene-related peptide (CGRP) inhibitors are now considered a first-line treatment used to treat and prevent migraines. There are two types of CGRP medications: monoclonal antibodies and ...

SGLT2 inhibitors were associated with a significant 28% risk reduction (hazard ratio [HR], 0.72; P = .018). When composite primary endpoint events were assessed separately, the rate of death at 1 ...

Inhibitors of Apoptosis Proteins (IAPs) are a family of anti-apoptotic proteins that play a pivotal role in apoptosis in general but also as oncoproteins in cancer progression and, more importantly, ...

In this article, explore how the research into blocking these checkpoints has led to immune checkpoint inhibitors (ICIs), a promising but still evolving class of immunotherapy that falls under the ...

Glycoprotein nonmetastatic melanoma protein B (GPNMB ... In addition, dcSSc fibroblasts secreted higher levels of soluble (s)GPNMB (147.4 ± 50.2 pg/ml vs. 84.8 ± 14.8 pg/ml, p<0.05), partly due to ...

3,8 As dextromethorphan is a substrate for CYP2D6 and quinidine is an inhibitor of CYP2D6 and p-glycoprotein, there is the potential for drug interactions. 44 Dose reductions of desipramine ...