The purpose of this study was to investigate the combination of doxorubicin with the pro-apoptotic BCL-2 inhibitor venetoclax in TNBC cell lines and to assess the role of p53 in cellular senescence ...

研究人员开展抗癌化合物研究，发现血根碱对 p53、VEGF、Bcl-2 有作用，有望用于癌症预防。 癌症预防意味着在癌症发展的初始阶段进行抵抗，抑制血管生成并启动癌细胞凋亡。通过虚拟筛选、结合自由能计算和分子动力学模拟，研究人员得以识别出具有潜在抗癌 ...

MCL-1保护激活的毛囊干细胞，驱动成人毛发再生，与P53抗衡生死，与BAK博弈命运，ERBB信号为其撑腰，解锁再生奥秘。 毛囊的生命旅程就像一场循环不息的舞蹈，生长期活力四射，退化期悄然谢幕，休眠期静待重生。为了探寻MCL-1这位BCL-2家族成员的秘密，我们在 ...

在全球所有癌症类型中，肺癌的发病率和死亡率最高。小细胞肺癌（SCLC）约占所有新诊断肺癌病例的 13%，被认为是侵袭性最强的亚型。含铂化疗，尤其是顺铂，过去几十年一直是 SCLC 治疗的基石。尽管大多数 SCLC ...

2025年4月7日，生物医学界迎来了重磅消息：再生医学公司CelularityInc.(Nasdaq:CELU)发布了一项重要研究，探讨了自然杀伤（NK）细胞与衰老、癌症之间的复杂关系。这项研究的关键论文题为《Senescence, NK cells, and cancer: navigating the crossroad of aging and disease》，刚刚在专业期刊《Fronti ...

Alopecia is an autoimmune disorder that causes non-scarring hair loss on the scalp and body that is experienced by almost 2% of the global population at some point in their lifetime.

Ascentage Pharma Group International’s AAPG share price has dipped by 6.94%, which has investors questioning if this is right ...

肝癌治疗手段有限，为探索新疗法，研究人员开展了氧化钇纳米颗粒（ Y 2?O3? NPs）对 Hep-G2 肝癌细胞影响的研究。结果发现 Y 2?O3? NPs 能显著抑制细胞活力、诱导细胞凋亡等。这为肝癌治疗提供了新方向，具有重要意义。

11–13 In addition, NO was reported to activate the apoptosis pathway by regulating antiapoptotic BCL-2 family members and the tumour suppressor p53.14 15 Based on these previous findings, we ...

Mol Cancer Ther (2025) 24 (4): 497–510. Murine double minute 2 (MDM2) is an E3 ligase that inhibits the tumor suppressor protein p53. Clinical trials employing small-molecule MDM2/p53 interaction ...

2024年对创新药企亚盛医药（AAPG. NASDAQ；6855.