A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery ...

Essential to the oncogenesis of HPV is the function of the viral protein E6 and its role in degrading the cell cycle regulator p53. Degradation of p53, and the resultant loss of cell cycle control, is ...

为探究衰老细胞中基因组不稳定与炎症的关联，研究人员聚焦 p53，发现其可抑制 CCF 积累及炎症，或为衰老相关疾病治疗提供新靶点。 在生命的长河中，衰老就像一个无法避免的 “关卡”，它带来了身体机能的衰退，还让我们更容易患上各种疾病。随着年龄的 ...

The DREAM repressor complex regulates genes involved in the cell cycle and DNA repair, vital for maintaining genome stability. Although it mediates p53-driven repression through the canonical ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Oscillatory p53 expression occurs in ...

Targeted protein degradation is a therapeutic strategy that utilizes the cell’s natural machinery to eliminate disease-causing proteins. The field traces its origins to the development of ...

Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China Introduction: The recombinant human p53 adenovirus (Ad-p53) offers a ...

1The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University & Guangdong Provincial Key Laboratory of Protein Modification and Degradation, ...

1Department of Radiation Oncology, Inselspital Bern University Hospital, Bern, Switzerland. 2Department for BioMedical Research, Radiation Oncology, University of Bern, Bern, Switzerland. 3Graduate ...

In response, we propose DaAIR, an efficient All-in-One image restorer employing a Degradation-aware Learner (DaLe) in the low-rank regime to collaboratively mine shared aspects and subtle nuances ...