SickKids researchers identified the KCNB2 gene as a key driver of medulloblastoma tumor growth. Blocking KCNB2 disrupts potassium channels, causing tumor-propagating cells to swell and lose integrity.

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

Our collaborators at the Institut Curie, Paris and NCNP, Tokyo have shown that signalling through the non-receptor tyrosine kinase SRC is upregulated in Group 4 medulloblastoma and furthermore, that ...

A study published in Nature Genetics reveals new insights into how medulloblastoma, the most common malignant brain tumor of childhood, can arise as the cerebellum develops. Researchers discovered ...

Introduction: Primary cilia play an important role in the development of cancer by regulating signaling pathways. Several studies have demonstrated that women with BRCA mutations have, on average, 50% ...

Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts. *Corresponding Author: Yogesh K. Chutake, Kymera Therapeutics, Inc., 500 North Beacon ...

Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco, San Francisco, United States Department of Psychiatry, Weill Institute for Neuroscience, University ...

This therapy focuses beams of high-energy radiation on the tumor tissue and a small amount of surrounding tissue. Some tumors, such as medulloblastoma, require additional radiation to the entire brain ...