The improper segregation of chromosomes during cell division leads to abnormalities that disrupt the proper functioning of the cell. Cells with an abnormal number of chromosomes consequently ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

During an extended mitosis PLK1 triggers the formation of a Mitotic Stopwatch Complex that stabilizes and activates the tumor suppressor p53.