p53 调节 FBXO33 在 GBC 中的功能且与 FBXO33 表达呈负相关 ... 双荧光素酶报告基因检测和 ChIP-qPCR 分析表明，YY1 可结合到 FBXO33 启动子区域促进其转录。 YY1 对 FBXO33 的转录激活依赖于 YY1 的乳酸化修饰：鉴于蛋白质乳酸化修饰在基因表达调控中的重要作用，且 YY1 ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.