Validation was performed using the E-MTAB-8248 cohort (n = 223). The expression levels of AURKA and CENPA were evaluated via RT-qPCR in two clinical NB sample groups. Results: Eight SRGs were ...

p53 调节 FBXO33 在 GBC 中的功能且与 FBXO33 表达呈负相关 ... 双荧光素酶报告基因检测和 ChIP-qPCR 分析表明，YY1 可结合到 FBXO33 启动子区域促进其转录。 YY1 对 FBXO33 的转录激活依赖于 YY1 的乳酸化修饰：鉴于蛋白质乳酸化修饰在基因表达调控中的重要作用，且 YY1 ...

MANILA – The Philippine Economic Zone Authority (Peza) has approved P52.93 billion worth of investment pledges in the first two months of the year. PEZA reported Tuesday that its investment ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.

5Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, ...

The p53 knockout cell lines, MCs-KO1, MCs-KO2 and KONC (negative control for knockout ... Complementary DNA (cDNA) was synthesized using a PrimerScript real-time reagent kit (Takara Biotechnology, ...

It is being increasingly appreciated that the immunomodulatory functions of PARP1 inhibitors (PARPi) underlie their clinical activities in various BRCA-mutated tumors. PARPi possess both PARP1 ...