BVDV 诱导细胞自噬：透射电镜观察到 BVDV 感染细胞中自噬泡和自噬溶酶体数量显著增加。qPCR 和 Western blot 分析发现，感染后 ATG7 mRNA 和蛋白表达上调，自噬底物蛋白 p62 水平下降，LC3-II/LC3-I 比值升高，表明 BVDV 感染可诱导 MDBK 细胞自噬，且呈时间依赖性。

Abnormal autophagy is a key factor in the development of AS ... China); Antibodies against Beclin1, LC3B, P62, CD31, VEGF, TNF-α, and IL-10 were purchased from Proteintech (Wuhan, China); Antibodies ...

Day 1: Cold exposure triggered autophagy dysfunction, with increased p62 (a marker that normally decreases during successful autophagy) and elevated cell death signals (cleaved-caspase-3) and ...

COTABATO CITY — Sixteen Bangsamoro lawmakers provided hospitals and rural health units (RHUs) in the autonomous region with P62.1 million worth of financial support, ambulances and other ...

They found that mRNA-based COVID-19-vaccinations cause a significant and persistent change through acetylation, i.e., the binding of a chemical group to specific, immunologically relevant genes of ...

Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages. Molecular Systems Biology , 2025; DOI: 10.1038/s44320-025-00093-6 Cite This Page : ...

uses a powerful monitoring system to reveal how the human immune system is responsive to a litany of tick triggers — some of which might be leveraged to create a protective mRNA vaccine.

The vaccine — using messenger RNA (mRNA) technology similar to that found in some Covid vaccines — activated tumour-targeting immune cells that persisted for nearly four years after surgery in ...

During starvation-induced autophagy, ATG2A undergoes depalmitoylation as the balance between ZDHHC11-mediated palmitoylation and APT1-mediated depalmitoylation. Inhibition of ATG2A depalmitoylation ...

Key suits were filed by third party mRNA and lipid pioneers that, while not having any mRNA-based products on the market themselves, leveraged their patent portfolios claiming a share of the ...