F) Absolute cell counts measured after 24h growth. Mann-Whitney test, p<0.05. G) Representative immunofluorescent localization of proliferating (PCNA marker) PASMC (ACTA2, yellow arrow) and PAAF ...

沉默 NSD2 可以减少肺动脉中的 H3K36me2，抑制自噬，从而减轻肺动脉壁和右心室的增厚。此外，JMJD1C 通过激活 STAT3 信号通路促进糖酵解，进而促进 PASMC 的增殖和肺血管重塑，而沉默 JMJD1C 则可以减少糖酵解酶的表达，减轻肺动脉高压。 主动脉疾病 主动脉疾病 ...

College of Pharmacy (X.S., Y.X., M.L., X.G., H.L., H.S., C.M., L.Z., X. Zhao, D.Z.) Central Laboratory of Harbin Medical University (Daqing), P.R. China (X.S., Y.X ...

该研究首次揭示了硫化氢（H?S）通过过硫化修饰内皮素A型受体（ETAR）蛋白第69位半胱氨酸巯基基团，抑制肺动脉平滑肌细胞（PASMC）增殖，抑制肺动脉高压的新机制。 该论文的通讯作者为北京大学第一医院儿童医学中心金红芳教授和黄娅茜研究员，第一作者为 ...

Two gene clusters were retrieved in the CIN network and three in the CC network. Multi-algorithmic topological analysis revealed PCNA as the highest ranked hub gene between the two networks, both in ...