Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ-PKAc fusion oncoprotein. However, the underlying mechanism of DNAJ-PKAc’s ...

Led by Friends, collaborators included Biodesix alongside organizations from industry, government, academia, and advocacy ...

The advent of digital droplet PCR (ddPCR) has marked a paradigm shift in molecular diagnostics, offering unparalleled sensitivity, precision, and reproducibility. Within the domain of forensic science ...

近年来，新辅助免疫治疗正在改变非转移性可切除实体瘤患者的治疗格局。比如，在一些临床试验中，新辅助免疫治疗后达到完全病理缓解（pCR）的实体瘤患者甚至可以考虑不做后续手术。因此，找到可以预测患者新辅助免疫治疗后能否实现pCR的生物标志物 ...

High-purity tube strips are batch certified by an independent laboratory to be free of DNase, RNase, human and bacterial DNA, and PCR inhibitors. Flat, optically transparent lid chains are available ...

Digital PCR was therefore more sensitive and more ... With targeted therapy using tyrosine kinase inhibitors (TKIs), patients with CML may achieve deep molecular responses. Patients who reach ...

Digital PCR was therefore more sensitive and more ... With targeted therapy using tyrosine kinase inhibitors (TKIs), patients with CML may achieve deep molecular responses. Patients who reach ...

Researchers have found that the clinical application of BCR::ABL1 digital PCR can reliably quantify stable deep molecular remission of chronic myeloid leukemia (CML), which will help to determine ...

New Chemistry Unit and School of Advanced Materials (SAMat), Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore 560064, India ...

However, the behind-the-scenes process of analyzing forensic DNA is far more intricate, requiring careful interpretation of the data. Forensic DNA profiling uses polymerase chain reaction (PCR) to ...

real-time PCR was carried out using Power TB Green PCR Master Mix (Takara ... The Pro-IL-37 becomes Mat-IL-37 after cleavage by Caspase-1, as pretreatment with Caspase-1 inhibitor (VX-765) almost ...

Historically, testing matrix metalloproteinase inhibitors (MMPIs) for the therapy of invasive or metastatic cancers has not yielded the expected beneficial results, but has had a positive effect ...