▎药明康德内容团队编辑（来源：复旦大学）近日，复旦大学附属华山医院刘杰教授、骆菲菲研究员团队在《肿瘤细胞》（Cancer Cell）发表题为“Targeting tumor monocyte-intrinsic PD-L1 by rewiring ...

为解决难治性卵巢癌免疫治疗效果不佳的问题，研究人员探究菊苣酸（CA）联合 PD-1/PD-L1 阻断剂的疗效，发现联合治疗或可有效治疗卵巢癌。 研究人员采用了多种关键技术方法。首先构建了患者来源的异种移植（PDX）模型，用化疗耐药的晚期 HGSC 患者的恶性腹水和外周血单个核细胞（PBMC）注入免疫缺陷的 NSG 小鼠，成功建立了免疫活性的 PBMC-PDX 模型。接着运用单细胞 RNA ...

Recently, the research team led by Professor Zhang Zhongtao and Professor Yao Hongwei from the General Surgery Center at ...

Phase III DIPPER trial shows that adjuvant camrelizumab administered after induction-concurrent chemoradiotherapy ...

as well as animal models lacking PD-1 signaling. The researchers found that impaired or absent PD-1 activity can significantly reduce the diversity and quality of antibodies produced by memory B ...

In the arthritic environment, Treg cells exhibit altered metabolic activity, reduced suppressive function, and increased PD-1 ...