研究人员探究反复着床失败（RIF）病因，发现 Wnt/β -catenin 和 PI3K-AKT-mTOR 通路异常，为 RIF 治疗提供新思路。 ### 反复着床失败：生育难题背后的分子秘密 在生育的奇妙旅程中，反复着床失败（Recurrent implantation failure，RIF）成为了许多夫妻难以跨越的障碍。

本研究针对肝细胞癌(HCC)中miRNA异常调控的临床难题，研究人员通过RT-qPCR、双荧光素酶报告基因等技术，揭示了miR-518b通过靶向 ...

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

Anaplastic thyroid cancer (ATC), a rare yet highly aggressive malignancy, continues to represent a major clinical challenge.

Our laboratory is dedicated to understanding the consequences of activation of these pathways and to using this information to develop mechanism-based therapeutic strategies. The laboratory is ...

The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These ...

Signaling in the PI3K/AKT/mTOR pathway is often disrupted in cancers, including ovarian cancer, Herzog noted in his introduction. In particular, key downstream pathways are mediated by AKT.