This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

CD37 缺失对正常造血影响较小，但显著影响 AML 的维持和 LSCs 的功能。转录组测序和验证实验揭示，CD37 通过整合素介导的 PI3K - AKT - BCL2/P27 信号通路调节其下游靶点。 虽然本研究为 AML 的靶向治疗提供了新的思路，表明 CD37 是免疫治疗的安全有效靶点，但仍存在 ...

Yale Cardiovascular Research Center CT, Yale University School of Medicine, New Haven, CT.(H.D., A.E., M.A.S.) Section of Cardiovascular Medicine, Department of ...

本研究针对胎盘植入谱系(PAS)这一威胁母婴生命的妊娠并发症，通过LC-MS/MS代谢组学分析发现L-精氨酸(L-Arginine)在PAS患者胎盘中 ...

Hepatocellular carcinoma (HCC), the most prevalent type of primary liver cancer, represents a significant cause of cancer-related mortality. While our understanding of its pathogenesis is ...

This important study suggests that the composition of the extracellular matrix in a mouse model of liver fibrosis changes depending on the cause of liver fibrosis. The data could be used as a ...

Background Injured or reactive biliary epithelial cells participate in most chronic liver injuries in a process referred to as ductular reaction, which involves multicellular interactions with marked ...

In combinatorial treatments, miltirone synergistically enhanced cytotoxicity of cisplatin in GC cells. Moreover, the expression levels of 606 genes appeared to be significantly modulated by miltirone ...

Zhejiang Provincial Key Lab for Chemical and Biological Processing Technology of Farm Product, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou ...