The team is optimizing the cancer genome analysis system to integrate it into CRC diagnosis and tailor treatments based on genetic mutations.

During development, cells grow, expand, and migrate to generate tissues and organs in a highly controlled manner. Many intracellular pathways—series of signaling cascades within a cell—regulate these ...

As key roles in cancer have been established for PI3K and PTEN — enzymes that regulate the levels of phosphatidylinositol-3,4,5-trisphosphate — compounds targeting this pathway are entering ...

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer ...

Lipid phosphatases such as phosphatase and tensin homolog (PTEN) are key in establishing this intracellular lipid gradient. The authors found that PI3K-generated lipids become polarized inside ...

AKT inhibitor Truqap (capivasertib) has been cleared by NICE for use in combination with standard therapy fulvestrant for ...

The PI3K/Akt/mTOR pathway controls cell growth and metabolism through Akt activation and downstream targets like mTORC1/2, p70S6K1, and 4E-BP1. Mutations in PIK3CA and loss of PTEN contribute to ...

NEW YORK – The UK's National Institute for Health and Care Excellence (NICE) on Friday recommended that the National Health Service make AstraZeneca's AKT pathway inhibitor Truqap (capivasertib) with ...

Compare that to Faslodex alone in patients with tumors harboring PI3K, AKT, or PTEN alterations (based on a hazard ratio of 0.50, p=<0.001; median PFS 7.3 versus 3.1 months). Price Action ...

or the loss of a tumor-suppressing protein called PTEN. "Up to 25–40% of BC cases exhibit variations that hyperactivate the PI3K/Akt/mTOR pathway, underscoring its critical role in oncogenesis." ...

Mutations in PIK3CA, AKT1, and alterations in PTEN occur frequently ... approval of Truqap “reinforces the important role of the PI3K/AKT pathway in HR-positive breast cancer and the critical ...

One of these pathways is the PTEN / PI3K axis, a complex series of perfectly balanced chemical reactions. Mutations in the PTEN gene usually result in the overactivation of PI3K and the imbalance ...