TFE3 fusion proteins are the oncogenic drivers of translocation renal cell carcinoma but their mechanism of action remains ...

lack adapter subunits and preferentially use PtdIns and PtdIns(4)P as substrates 6. Three mammalian class II isoforms have been identified: the ubiquitously expressed PI3K-C2α and PI3K-C2β ...

Functional analyses support that this mutation specifically impairs Nef`s ability to stimulate PI3K/Akt/mTORC2 signalling. This important study suggests that the accessory viral protein Nef impairs B ...

In the case of signaling through chemokines and their G-protein-coupled receptors (GPCRs), GTP-bound Gαi directly activates SRK-like kinases, which upregulate phosphatidylinositol 3 kinase (PI3K) ...

This study clearly shows that m6A modification on mRNA regulates immune responses in the intestine during rotavirus infection. The authors further show the mechanisms how m6A modification is regulated ...

An alternative explanation is that mutation of S861 negatively affects Akt phosphorylation of another site. Several pieces of evidence indicate that Akt acts downstream of PI3K to regulate HCN2. First ...