然而，柚皮苷对宫颈癌的具体作用机制仍有待深入探讨。PI3K/Akt/mTOR通路是一条重要的细胞信号传导通路，涉及多种细胞刺激的激活，其功能在肿瘤的发生、进展和药物反应中起着至关重要的作用。通过靶向PI3K/Akt/mTOR通路的药物，已在多个研究中被证实可以抑制肿瘤的发展。因此，深入研究柚皮苷在宫颈癌细胞中对PI3K/Akt/mTOR通路的影响，不仅为宫颈癌的临床治疗提供了新的思路，也为开发新的 ...

肿瘤治疗电场（TTFields）已用于治疗多种癌症，但部分患者疗效不佳。为探究原因，研究人员开展 TTFields 与 PI3K/AKT 通路关系的研究。结果发现 PI3K/AKT 通路参与癌细胞对 TTFields 的反应，抑制该通路可增敏。这为提升 TTFields 疗效提供新思路。

The results of the KEGG pathway enrichment analysis of YQQRG and renal fibrosis were combined, which showed that YQQRG’s renoprotective effects were strongly associated with the phosphatidylinositol 3 ...

Western Blot（蛋白免疫印迹）是分子生物学中检测特定蛋白表达的“金标准”，但其复杂的步骤和细节常让新手头疼。本文将从原理、实验步骤、常见问题及解决方案三方面入手，带你彻底掌握这项技术！ SDS（十二烷基硫酸钠）使蛋白带负电荷，消除形状差异 ...

Western is one of the most iconic and distinctive genres in cinema and television. From sprawling ranches to dusty towns, rugged cowboys in hats to intense gunfights at high noon, westerns have a way ...

URUMQI, China—About a decade ago, some Western companies answered Beijing’s calls to invest in Xinjiang, an underdeveloped region in the country’s remote west. Some were drawn by the natural ...

这进一步证实了 miR-374-5p 在体外能够抑制成骨细胞的分化和骨基质的沉积与矿化34。 miR-374-5p 与 PI3K/AKT 通路的相互作用：Western blot 分析表明，miR-374-5p 模拟物转染可显著增强 AKT 磷酸化水平，而抑制剂则降低其表达。通过共转染 miR-374-5p 模拟物和 PI3K/AKT 通路抑制 ...

Many Western businesses, though, remain cautious. Security is often the concern, and one that may preoccupy Americans more than Europeans. One American boss says he would only run DeepSeek’s ...

The expression levels of BAX, BCL-2, AKT, PI3K, and PD-L1 were assessed by quantitative PCR and Western Blot. Results: IFN-γ- and sPD-1-overexpressing BMSCs exhibited high bioactivity and genetic ...

and cyclooxygenase-2 (COX-2), according to western blot analyses. BBR inhibited the expression of F-actin, a key protein in phagosome formation. Notably, BBR exerted its phagocytosis effects through ...