Solution-state nuclear magnetic resonance (NMR) spectroscopy is the classical NMR spectroscopy approach used for molecular structure determination, where the experimental sample is studied while ...

为探究 IER5 的细胞功能及作用机制，研究人员开展了 IER5 对 PP2A/B55α 磷酸酶作用的研究。结果发现 IER5 是 PP2A/B55α 的核内抑制剂，明确了结合位点和抑制机制，还发现类似蛋白也存在相似作用，为调控 PP2A/B55α 提供理论基础。 IER5 是 AP1 调控的即刻早期反应（IER ...

“PPP2R1A is a gene that encodes the most common scaffold component of a protein phosphatase, [protein phosphatase 2A (PP2A)], which is a ubiquitous serine/threonine phosphatase implicated in diverse ...

编辑推荐：针对丝氨酸/苏氨酸磷酸酶缺乏特异性抑制剂的难题，Lindsey A. Allan团队开发了"directSLiMs"系统，通过药物诱导的SLiM肽 ...