阿尔茨海默病（Alzheimer’s disease，AD）作为一种常见的神经退行性疾病，严重影响着人们的健康和生活质量。随着全球老龄化进程的加速，AD 的发病率逐年上升，给社会和家庭带来了沉重的负担。目前，虽然对 AD 的研究已经取得了一些进展，但对于其发病机制仍未完全明确。在 AD 的众多发病因素中，衰老被认为是最主要的风险因素。然而，神经元蛋白稳态（proteostasis）下降与 AD ...

These pages give an overview of what genes are and how they are involved in the different diseases that cause dementia. You will also find information about genetic testing for dementia. Genes ...

Suppressing KCTD20 in both the organoids and mice prevented glutamate from triggering tau accumulation and neurodegeneration. Further experiments showed that blocking this gene’s activity activated ...

This month's cover highlights the article Natural variations of adolescent neurogenesis and anxiety predict the hierarchical status of adult inbred mice by Nicolas Toni, Thomas Larrieu and colleagues.

Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, ...

State Key Laboratory of Polymer Science and Technology, Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China School of ...

Department of Medicinal Chemistry, University of Kansas, Lawrence, United States Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard ...

Lysosome-related organelles (LROs) or granules are the main protease storage and processing organelles of the endolysosomal system. The range of proteases present in LROs is cell-type specific.

Obesity is one of the more prevalent diseases, which results in energy imbalance within metabolic tissues and lysosome dysfunction. Less frequent diseases include Niemann-Pick type C (NPC) and Gaucher ...

As the primary adenosine triphosphate-generating organelles, mitochondria are well-known regulators of stem cell fate decisions, yet it is now becoming apparent that additional organelles such as the ...

Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases. However, the mechanisms elicited by ...