Several genetic variants in APP, PSEN1, and PSEN2 fit the bill, but not all. A study led by Jorge Llibre-Guerra of Washington University in St. Louis, published February 4 in Brain, explains how the ...

GBA1 mutations alone do not explain lysosomal dysfunction in PD. Loss of endosomal recycling proteins cripple this lysosomal enzyme. Without a protein called COMMD3, cells spit out would-be lysosomal ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.

Department of Chemistry, Shanghai Stomatological Hospital, State Key Laboratory of Molecular Engineering of Polymers and Institute of Biomedical Sciences, Fudan University, Shanghai 200433, People’s ...

The company’s approach is somewhat akin to the enzyme replacement therapies used to treat lysosomal storage disorders like Fabry or Pompe disease. Glycomine’s therapy is replacing a missing sugar ...

研究成果发表在《Chinese Medicine》杂志上。 研究人员采用了多种关键技术方法。首先，选用 5xFAD 小鼠（一种常用的 AD 动物模型，通过过表达含有五个家族性 AD 相关突变的 APP 和 PSEN1 基因构建而成）和野生型 C57BL/6J 小鼠，将 5xFAD 小鼠分为三组，分别给予低剂量 ...

There are more than 70 known lysosomal storage disorders (LSDs). These rare neurodegenerative diseases are characterized by the dysfunction of lysosomes, cellular organelles that break down ...

Department of Biospectroscopy and Bioelectrochemistry, Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio av. 7, Vilnius LT-10257, Lithuania ...

Using CRISPR interference to screen the entire genome, scientists identified how Commander proteins impact lysosomal function — a key cellular recycling system tied to Parkinson’s pathology. These ...

哪些人群需要特别注重筛查阿尔茨海默病？商慧芳表示，淀粉样蛋白前体基因（APP）、早老素1（PSEN1）、早老素2（PSEN2）这三个基因是非常明确的 ...

These harmful variants reduce the activity of an enzyme called glucocerebrosidase (GCase), which is important for cells' recycling process in lysosomes. However, it has been unknown why some ...