PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

Several genetic variants in APP, PSEN1, and PSEN2 fit the bill, but not all. A study led by Jorge Llibre-Guerra of Washington University in St. Louis, published February 4 in Brain, explains how the ...

Different variants of the γ-secretase complex contain either PSEN1 or PSEN2, which affects where it is located within the cell and suggests that the two have slightly different functions.

The following genes that make up the gamma-secretase complex may develop mutations that can increase your risk of developing HS: Nicastrin (NCSTN) Presenilin 1 (PSEN1) Presenilin enhancer 2 ...