A new review was published in Oncotarget, Volume 16, on March 13, 2025, titled "Signaling pathway dysregulation in breast cancer." In this review article, Dinara Ryspayeva and colleagues from Brown ...

Innovations in therapeutic strategies, coupled with a deeper understanding of breast cancer biology, will be essential for advancing personalized ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Researchers have revealed for the first time how a key protein linked to Parkinson's mutates, leads to cell death in the ...

Leiden, the Netherlands, March 13, 2025: Pharming Group N.V. (“Pharming” or “the Company”) (Euronext Amsterdam: PHARM / Nasdaq: PHAR) presents its preliminary (unaudited) financial report for the ...

Reducing PTEN overexpression or inducing PTEN mutation may increase the degree of inhibition of ferroptosis by the PAM pathway, thus achieving protection from PD. Figure 2. The diagram of the PI3K/AKT ...

It has been about a month since the last earnings report for Patterson-UTI (PTEN). Shares have lost about 14.7% in that time frame, underperforming the S&P 500. Will the recent negative trend ...

Current chemotherapy regimens have modest survival benefit. Thus, novel, effective therapies are required for treatment of this disease. Results We found that tumours in KRAS PTEN mice exhibit a ...

What are the upstream signaling mechanisms that regulate PHLPP-1 activity under basal conditions or during I/R? Moreover, what is the relationship between PHLPP-1 and other phosphatases such as PTEN ...