The brain disease model of addiction has dominated public and scientific discourse on addiction (termed substance use disorder [SUD] in the DSM-5) over the past 3 decades. The model framed addiction ...

Scientists now present a new organoid model that reveals details ... 1 is specific for microglia. "Our paper shows that it is critical to have microglia brain organoid models to mimic inflammatory ...

This model could influence pharmaceutical testing ... by inhibiting two inflammatory enzymes—COX 1 and COX 2—of which COX 1 is specific for microglia. “Our paper shows that it is critical to have ...

Model allowed researchers to better understand the complex molecular mechanisms that determine the robustness, flexibility, ...