Whether these effects are NAADP or PI(3,5)P 2 dependent however remains currently unclear. In sum, recent evidence suggests that TPCs are involved in a multitude of immune cell functions, reportedly ...

In a first line of research, we study how bacterial polyP modulates macrophage functions, including phagosome acidification, lysosome activity, autophagy, and cell polarization, facilitating bacterial ...

View Full Profile. Learn about our Editorial Policies. B.H. Abuaita et al., “Mitochondria-derived vesicles deliver antimicrobial reactive oxygen species to control phagosome-localized Staphylococcus ...

Parkinson’s disease (PD) is a major and progressive neurodegenerative disorder, yet the biological mechanisms involved in its aetiology are poorly understood. Evidence links this disorder with ...

Macrophages are highly plastic cells with critical roles in immunity, cancer, and tissue homeostasis, but how these distinct cellular fates are triggered by environmental cues is poorly understood. To ...

Cover picture: Drosophila adult thorax split in half with all nuclei in blue, all muscles in green and the 100s of nuclei of the large flight muscles in red. FM image provided by the authors of the ...