结果发现 FDX1 可增强 ES 抗癌效果，通过激活 IRF3/IFN-β 信号通路诱导 PANoptosis，为 DLBCL 治疗提供新策略。 弥漫大 B 细胞淋巴瘤（Diffuse large B-cell lymphoma，DLBCL）仍是临床治疗的一大挑战，需要开发新的治疗方法。铜死亡（cuproptosis）作为一种新发现的铜诱导细胞 ...

Rosalind Franklin Univ. of Med. & Science, North Chicago, IL.

本研究揭示了HBV表面抗原(HBsAg)通过靶向TBK1激酶结构域增强其二聚化但破坏TBK1-IRF3复合物，从而抑制I型干扰素(IFN-β)产生并促进p62介导的自噬起始，同时通过抑制SNAP29启动子阻断自噬体-溶酶体融合。该发现为理解HBV免疫逃逸和持续性感染提供了新视角，发表于 ...

Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong 510055, China Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University, ...

PrP C 通过其液-液相分离（LLPS）的能力激活了 TBK1-IRF3 信号通路，从而促进了 PTEC 和成纤维细胞的促纤维化反应。 在肾纤维化发生之前（在单侧输尿 ...

This manuscript presents important findings on a bacterial effector involved in plant symbiotic signaling. The effector proteolytically targets a key receptor while its activity is counteracted by ...

Modulating GRAMD1B in iPSC-derived neurons also alters key autophagy-related components such as PI3K, phospho-AKT, and p62, as well as phosphorylated tau, and CDK5R1. Blocking GRAMD1B function ...

传统抗HSV-1药物均靶向病毒DNA聚合酶，近年来耐药性问题日益突出。本研究首次发现HSV-1 UL38蛋白能直接靶向宿主抗病毒免疫关键蛋白STING，抑制其与第二信使cGAMP的结合，破坏STING与TBK1及IRF3的互作，抑制干扰素信号通路。通过解析UL38与STING的相互作用界面 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Glioblastoma multiforme (GBM) is the most ...

Interferon regulatory factor 5 (IRF5) is a critical transcription factor in the IRF family, playing a pivotal role in modulating immune responses, particularly within the innate immune system. IRF5 ...