这项研究揭示了赖氨酸甲基转移酶SMYD3在调节抗病毒先天免疫中的作用，并为影响其激活的IRF3的调节机制提供了新的见解。 研究表明，对睡眠、运动 ...

cGAS-STING通路是固有免疫系统识别胞质DNA并启动免疫应答的重要分子开关，其下游包括IRF3-I型干扰素（IFN-I）和NF-κB两条主要的信号轴，在肿瘤等重大 ...

In the rare case of an antibody penetration problem or damage, the top 30 μm of the z-stack were analyzed. Phospho-tau (AT8), presynaptic terminal (SYP), inflammatory cytokine (TNFα, IL1-β), and DNA ...

It is being increasingly appreciated that the immunomodulatory functions of PARP1 inhibitors (PARPi) underlie their clinical activities in various BRCA-mutated tumors. PARPi possess both PARP1 ...

Table 1 shows sequences used for amplification of target genes. Antibodies to detect the phosphorylated p-65 NF-κB subunit Cat #3031 (AB_330559), phosphorylated c-Jun subunit Cat #9164 (AB_330892), ...

MAVS forms large prion-like polymers that activate the cytosolic kinases IKK and TBK1, which in turn activate NF-κB and IRF3, respectively, to induce interferons. Here we show that MAVS polymers ...